Too large for destination file system usb

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For many users, it is really strange to see such a message when there is plenty of storage is remaining. As per this issue, the error message says “the file is too large for the destination file system”. Windows users who try to copy large files (ISO files, Operating Systems, video collections, Movies, etc.) experience this issue. How to solve “too large for the destination file system” issue with EaseUS Partition Master? What is the cause behind “the file is too large for the destination file system” error?